15^th World Congress on Blood Cancer October 23-24, 2019 Prague, Czech Republic

PANAROMA HOTEL PRAGUE - Milevská 7, 140 63 Praha 4-Nusle, Czechia

Biography:

Prashant Pawar is an Interventional Cardiologist. He has done his research work in PVI for Paroxysmal Atrial Fibrillation. He has worked with Dr. Yash Lokhandwala the pioneer in EP study in India. He has many publications in his name. Present study was to evaluate PVI by conventional RF ablation.

Abstract:

Introduction: There is no Indian data on the outcome following conventional radiofrequency catheter ablation (RFA) for patients with paroxysmal atrial fi brillation (PAF). Inspite of recent advancements in this fi eld including sophisticated three dimensional (3D) based imaging and advanced ablation catheters with contact force technology, many Indian patients will not afford such an expensive therapeutic procedure. Here in this article we have summarized the immediate and long term outcome following RFA of Indian patients with PAF using pulmonary vein (PV) electrogram based mapping and using 8 mm tip ablation catheter.

Methods: Fourty two consecutive patients who underwent RFA for symptomatic PAF not controlled with atleast one antiarrhythmic drugs were studied in a tertiary care institute from March 2015 to December 2018. PVI was performed solely by conventional electrophysiology procedure using 8 mm tip RF catheter and PV potential electrogram based mapping. 3D mapping was not used. Only PVI was performed. Substrate modifi cation was not performed. Elimination of all ostial pulmonary vein potentials and complete entrance block into the pulmonary vein were considered indicative of complete electrical isolation. Follow-up visits were scheduled at four weeks, and three, six months post procedure, and every six months thereafter.

Results: After the procedure 34 were arrhythmia free, eight continued to have atrial fi brillation.

Conclusion: Conventional RFA using PV potential electrogram based mapping and ablation with 8 mm tip catheter is safe and effective for patients with PAF with satisfactory immediate and long term outcome and negligible complications and very cost effective in our setting with limited resources.

Biography:

Ibrahim Saleh Alharbi is currently working as an Internal Medicine Resident-R4 at the hospital of King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Abstract:

Introduction: The relationship between anemia and coronary artery disease (CAD) in general population is not well defi ned. While some studies demonstrated increased association between iron stores and CAD as evident with increasing rate of CAD in postmenopausal women, data regarding the effect of anemia on coronary microcirculation is limited. Therefore, we examined the effect of anemia on coronary microvascular function measured by hyperemic myocardial blood fl ow (MBF) and non-invasive coronary fl ow reserve (CFR) measured by Positron Emission Tomography (PET).

Methods: All consecutive patients referred for clinically indicated PET between May 2011 and December 2017 who had hemoglobin (Hb) on the day of the test were included in the analysis. Patients with prior CAD, ischemia (sum difference score > 1), scar (sum stress score >3), transient ischemic dilatation and abnormal resting left ventricular function were excluded. MBF was measured by single compartment method and CFR is calculated as stress MBF/rest MBF.

Results: A total of 320 patients (mean age 60 ± 10 yrs, 50% female) were included of which 117 patients had Hb <11 mg/dl. There were no differences in the prevalence of hypertension or diabetes between anemic and normal Hb patients. Using spearman correlation, there was a weak, but statistically signifi cant correlation between Hb and CFR (r=0.3589, p<0.0011) and peak MBF (r=0.1247, p=0.0258). Using multivariate linear regression, the correlations between Hb and CFR (Beta=6.03, p=<0.0001) and peak MBF (Beta=3.02, p=0.010) remained signifi cant after adjusting for confounders.

Conclusions: Our analysis suggests that anemia is associated with microvascular dysfunction measured by PET derived CFR. The therapeutic implications of these fi ndings require further testing in therapeutic studies.

Biography:

Muhammad Amin Baig is practicing in a dynamic and emerging fi eld of Alternative Medicines for last 22 years and now 12 years at F-10 Markaz Islamabad. He is an Executive Principal at SADRI Institute of Alternative Medicine, Chowk Azam District Layyah, Punjab. He is a Head of the Department of Alternative Medicine at Vertex College of Science and Technology Muzaffarabad, Azad Jammu and Kashmir. He was a Former Dean of Health Department in Mooreland College London. He has a Training Certifi cate Honorary Directorate of Hakim/Homoeopaths, Federal Ministry of Population, and Government of Pakistan. He was serving as a Chairman at International Alternative Medical Council (IAMC) Pakistan, Chairman at Sadri Foundation, and President at Society for Awareness, Development, and Research & Invention. He is a Professor and Head of Department of Cupping and Regimental Therapies at Ajmal Tibbia (Unani Medical) College, Rawalpindi, Pakistan. He is a Visiting Professor at The Open International University for Complementary Medicine, Colombo, Sri Lanka, Director General at International Council of Electro Homoeopathy, USA, and Chief Executive for Pakistan Chapter: IHMS & ANMA Inc. USA. He is a Consultant and Country Director at KEISIE International University, South Korea. He had International Membership with American Association of Acupuncture and Oriental Medicine, USA. International Holistic Medical Society (IHMS) California, USA.

Abstract:

Background: Ancient old technique of wet cupping commonly known as Hijama has proven its effectiveness in number of medical ailments including sciatic nerve pain. Long term study was to evaluate the effectiveness of wet cupping, after two years and fi ve years patients suffering from sciatic nerve pain.

Method: Two hundred fi fty patients were randomly selected having no previous physical injury, between ages 18-80 years. Wet cupping sessions were done on every alternate day; three sessions were done in which removal of subcutaneous blood with the help of glass suction cups was done after making superfi cial incisions. One cup was generally applied between shoulders at T1 and C7 vertebrae area, and two cups were applied on L3-L4 or L4-L5 and L5-S1 vertebrae. After these sessions the decrease in sciatic pain and improvement in quality of life of patient was assessed by visual analogue score, numeric pain rating scale, and WHOQOL scale at before treatment, after treatment, one year after treatment, two years after treatment, and fi ve years after treatment. (Data were analysed by paired t-test and ANOVA.)

Result: Out of 250 patients about 225 (90%) of patients have shown marked decrease in sciatic nerve pain. After one year of treatment 175 (70%) of patients were satisfi ed and doesn’t need any further treatment of sciatic pain, after two years of treatment more than 125 (50%) patients showed marked decrease in pain as compared to before treatment. Five years after treatment 92 (37%) of patients were enjoying good quality of life as shown by their WHOQOL scale.

Conclusion: Long term benefi ts of wet cupping in patients suffering from sciatic nerve pain was observed , it is concluded that overall quality of life of patient is improved and pain score is signifi cantly decreased after two years and fi ve years of Hijama treatment.

Biography:

Paola Vidal Rojo has completed her basic education by Cambridge University of London, has graduated from the Faculty of Medicine of the Universidad La Salle AC, and later graduated from the specialties of two of the largest Health Institutes in our country and in Latin America. She has initially in Pediatrics of Children's Hospital of Mexico, and later subspecialty in Pediatric Cardiology of the National Institute of Cardiology Ignacio Chávez, fulfi lling functions of Head of Residents of the subdivision of Pediatrics. And fi nally she is high specialty in Medicine in Pediatric and Fetal Echocardiography in the Children's Hospital of Mexico Federico Gómez.

Abstract:

Mexico is a country with many inequalities, which are very notable, amongst other things, in high tech healthcare. Congenital heart diseases require in average $5,000 USD per child for a surgical treatment. Given that our average per capita income is quite low, only as few as 10% of the population can aff ord such healthcare, and even though 98% of the population have some sort of social security service, these are saturated, and patients may have to wait up to two years to be able to have surgery. And more so, over two million people have no access to medical services. So, we must turn to social enterprises and non-profi t associations to be able to cope with this problem, and still are left with many patients without proper care. Th ere are several areas within the country that do not have extracorporeal pump machines for open heart surgery, so they must perform surgeries without them, such as corpectomy or pulmonary banding, some of which are palliative surgeries. Many of the patients we attend arrive relatively late, considering their state. For example, we operate tetralogies of Fallot aft er two years of age, or anomalous pulmonary venous connections aft er three months. All these because of lack of planning; we have the resources and the infrastructure, but we do not yet fi nd a way to properly manage these defi cits. And so, we have so far eight nonprofi t associations performing surgical procedures in congenital heart diseases throughout the country. Amongst all of them, over 1,000 children a year have been operated on, just a small percentage of all that we calculate are still awaiting surgery. Every year, more that 22,000 new children with congenital heart diseases are born, and we try to shorten the list. Th e fi rst non-profi t was founded in 1995, and the newest one barely this year. And all of them need mainly two things: Patients, and economical resources. We need pediatricians to redirect patients to the specialists as soon as possible and to begin medical treatment in case these referrals are not entirely feasible, and paediatric cardiologist to be familiar with all governmental, profi t and nonprofi t options for the patient’s benefi t. We intend with this paper to share our experiences and our results in case some other countries may fi nd it useful, as well as to urge the need for pediatric alertness, the need for resources (both human and economic), as well as an early referral, to be able to help all he children awaiting surgery to improve their quality of life.

Biography:

S Pandey has obtained his Master’s degree in Yogic Science and Human Consciousness, Gurukul Mahavidyalaya College Jawalapur, Haridwar from Uttarakhand Sanskrit University, Haridwar, India. He has completed his Diploma in Bachelor of Science (ZBC) in Biology from University of Lucknow, India. He began his teaching career in Yoga in Rishikesh and in fact become one of the famous teachers of Pranayama and Philosophy in Himalaya. He teaches in famous schools like Rishikesh School of Yoga and Ayurveda, World Peace Yoga School, Himalayan Yoga Academy, Swasti Yogshala and continues his activity till nowadays. He has experience of work in foreign countries and gives many international Workshops in Russia, Poland. He has teaches in Nepal, Tibet, Thailand, Russia and many other countries.

Abstract:

Background: Th e eff ect of yoga practice on the depression is evaluated worldwide. We assessed the eff ect of yoga on the depression, human’s energy and physical bodies in our institute and observed the correlation between subjective eff ect of practice and charts of GDV camera (energy body and chakra system).

Methods: Clients of detox yoga retreat program (asana, pranayama, meditation, special detox vegetarian or vegan nutrition daily) were participated in the study. Subjective eff ect of yoga practice was assessed with internal questionnaire, depression symptoms were evaluated with HRDS17 Scale. Th e relationships between the symptoms of depression, subjective eff ect of yoga practice and GDV charts before and aft er the program were examined. Results: One hundred four clients with a median age of 33, 3 years (18-73), out of 93.5% had positive subjective eff ect of the practice. Th e mean HRDS17 score was 12 (mild depression) before start of the program, aft er the competition of the program the mean score was four (normal). Th e amount of energy increased in 65% of cases; the chakra system was more align and stable in 75% aft er the practice.

Conclusion: Th ere is a need to develop eff ective yoga programs for preventive care of depression and explore therapeutic eff ect of yoga.

Biography:

Rim Frikha is an Associate Professor in Medicine and a PhD student at National School of Engineer in the University of Sfax. She is expert in Histology-Embryology and Molecular Genetic on Onco-Hematology. She has published numerous papers in reputed journals in these fi elds.

Abstract:

Introduction: High-dose methotrexate (HD-MTX) is widely used in the acute lymphoblastic leukemia (ALL). The effect of 5, 10-methylenetetrahydrofolate reductase (MTHFR) variants; mainly the C677T on the risk of MTX-induced toxicity was largely investigated and enrolled in meta-analysis. However, the results were inconsistent.

Aim: The aim of this study was to investigate the relationship between the C677T variant of the MTHFR gene, and the MTX-induced toxicity in Tunisian ALL patients.

Materials & Methods: It was a retrospective study among 35 patients with ALL. Toxicity data was recorded after high-dose methotrexate (HD-MTX) course. Genotyping of MTHFR C677T was performed by polymerase chain reactionrestriction fragment length polymorphism (PCR- RFLP).

Results: Patients with ALL carrying the C677T variant were at a higher risk of developing hepatotoxicity (RR=1.3 times).

Conclusion: The present result highlights the impact of MTHFR C677T variant on the MTX toxicity-induced in ALL and further studies with larger numbers of participants worldwide are required before defi nitive conclusions.